Evaluating the fibroproliferative response to ventilator-induced lung injury
نویسندگان
چکیده
Introduction: Acute Lung Injury (ALI), and its more severe subset the Acute Respiratory Distress Syndrome (ARDS), are a major cause of mortality in the Intensive Care Unit. Mechanical ventilation, a supportive therapy necessary to sustain life in many cases, may contribute to and worsen ALI, termed Ventilator Induced Lung Injury (VILI). Fibroproliferation is an early response to lung injury . Indeed dysregulated repair resulting in pulmonary fibrosis may be at the heart of ventilator dependence in ARDS . Characterising the role of excessive lung stretch in contributing to aberrant repair mechanisms would contribute to our understanding of VILI and assist in developing strategies to hasten recovery from ARDS.
منابع مشابه
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